Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues.
Identifieur interne : 000156 ( Main/Exploration ); précédent : 000155; suivant : 000157Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues.
Auteurs : Wuling Liu [République populaire de Chine] ; Krishnapriya M. Varier [Inde] ; Klarke M. Sample [République populaire de Chine] ; Eldad Zacksenhaus [Canada] ; Babu Gajendran [République populaire de Chine] ; Yaacov Ben-David [République populaire de Chine]Source :
- Advances in experimental medicine and biology [ 0065-2598 ] ; 2020.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , metabolism : Erythropoietin, Receptors, Erythropoietin.
- metabolism : Neoplasms.
- Erythropoiesis, Health, Humans, Signal Transduction, Tumor Microenvironment.
Abstract
Erythropoietin (EPO), the primary cytokine of erythropoiesis, stimulates both proliferation and differentiation of erythroid progenitors and their maturation to red blood cells. Basal EPO levels maintain the optimum levels of circulating red blood cells. However, during hypoxia, EPO secretion and its expression is elevated drastically in renal interstitial fibroblasts, thereby increasing the number of erythroid progenitors and accelerating their differentiation to mature erythrocytes. A tight regulation of this pathway is therefore of paramount importance. The biological response to EPO is commenced through the involvement of its cognate receptor, EPOR. The receptor-ligand complex results in homodimerization and conformational changes, which trigger downstream signaling events and cause activation or inactivation of critical transcription factors that promote erythroid expansion. In recent years, recombinant human EPO (rEPO) has been widely used as a therapeutic tool to treat a number of anemias induced by infection, and chemotherapy for various cancers. However, several studies have uncovered a tumor promoting ability of EPO in man, which likely occurs through EPOR or alternative receptor(s). On the other hand, some studies have demonstrated a strong anticancer activity of EPO, although the mechanism still remains unclear. A thorough investigation of EPOR signaling could yield enhanced understanding of the pathobiology for a variety of disorders, as well as the potential novel therapeutic strategies. In this chapter, in addition to the clinical relevance of EPO/EPOR signaling, we review its anticancer efficacy within various tumor microenvironments.
DOI: 10.1007/978-3-030-35582-1_2
PubMed: 32030683
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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Plants, Guizhou Medical University, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation></author><author><name sortKey="Varier, Krishnapriya M" sort="Varier, Krishnapriya M" uniqKey="Varier K" first="Krishnapriya M" last="Varier">Krishnapriya M. Varier</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai</wicri:regionArea><wicri:noRegion>Chennai</wicri:noRegion></affiliation></author><author><name sortKey="Sample, Klarke M" sort="Sample, Klarke M" uniqKey="Sample K" first="Klarke M" last="Sample">Klarke M. Sample</name><affiliation wicri:level="1"><nlm:affiliation>Central Laboratory, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, Guizhou, China.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Central Laboratory, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation></author><author><name sortKey="Zacksenhaus, Eldad" sort="Zacksenhaus, Eldad" uniqKey="Zacksenhaus E" first="Eldad" last="Zacksenhaus">Eldad Zacksenhaus</name><affiliation wicri:level="4"><nlm:affiliation>Department of Medicine, University of Toronto, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Medicine, University of Toronto, Toronto, ON</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Gajendran, Babu" sort="Gajendran, Babu" uniqKey="Gajendran B" first="Babu" last="Gajendran">Babu Gajendran</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, China. babug1986@gmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China. babug1986@gmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation></author><author><name sortKey="Ben David, Yaacov" sort="Ben David, Yaacov" uniqKey="Ben David Y" first="Yaacov" last="Ben-David">Yaacov Ben-David</name><affiliation wicri:level="1"><nlm:affiliation>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, China. yaacovbendavid@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China. yaacovbendavid@hotmail.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou</wicri:regionArea><wicri:noRegion>Guizhou</wicri:noRegion></affiliation></author></analytic><series><title level="j">Advances in experimental medicine and biology</title><idno type="ISSN">0065-2598</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Erythropoiesis (MeSH)</term><term>Erythropoietin (metabolism)</term><term>Health (MeSH)</term><term>Humans (MeSH)</term><term>Neoplasms (metabolism)</term><term>Receptors, Erythropoietin (metabolism)</term><term>Signal Transduction (MeSH)</term><term>Tumor Microenvironment (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Humains (MeSH)</term><term>Microenvironnement tumoral (MeSH)</term><term>Récepteur érythropoïétine (métabolisme)</term><term>Santé (MeSH)</term><term>Transduction du signal (MeSH)</term><term>Tumeurs (métabolisme)</term><term>Érythropoïèse (MeSH)</term><term>Érythropoïétine (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Erythropoietin</term><term>Receptors, Erythropoietin</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Récepteur érythropoïétine</term><term>Tumeurs</term><term>Érythropoïétine</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Erythropoiesis</term><term>Health</term><term>Humans</term><term>Signal Transduction</term><term>Tumor Microenvironment</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Humains</term><term>Microenvironnement tumoral</term><term>Santé</term><term>Transduction du signal</term><term>Érythropoïèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Erythropoietin (EPO), the primary cytokine of erythropoiesis, stimulates both proliferation and differentiation of erythroid progenitors and their maturation to red blood cells. Basal EPO levels maintain the optimum levels of circulating red blood cells. However, during hypoxia, EPO secretion and its expression is elevated drastically in renal interstitial fibroblasts, thereby increasing the number of erythroid progenitors and accelerating their differentiation to mature erythrocytes. A tight regulation of this pathway is therefore of paramount importance. The biological response to EPO is commenced through the involvement of its cognate receptor, EPOR. The receptor-ligand complex results in homodimerization and conformational changes, which trigger downstream signaling events and cause activation or inactivation of critical transcription factors that promote erythroid expansion. In recent years, recombinant human EPO (rEPO) has been widely used as a therapeutic tool to treat a number of anemias induced by infection, and chemotherapy for various cancers. However, several studies have uncovered a tumor promoting ability of EPO in man, which likely occurs through EPOR or alternative receptor(s). On the other hand, some studies have demonstrated a strong anticancer activity of EPO, although the mechanism still remains unclear. A thorough investigation of EPOR signaling could yield enhanced understanding of the pathobiology for a variety of disorders, as well as the potential novel therapeutic strategies. In this chapter, in addition to the clinical relevance of EPO/EPOR signaling, we review its anticancer efficacy within various tumor microenvironments.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32030683</PMID><DateCompleted><Year>2020</Year><Month>02</Month><Day>11</Day></DateCompleted><DateRevised><Year>2020</Year><Month>02</Month><Day>11</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0065-2598</ISSN><JournalIssue CitedMedium="Print"><Volume>1223</Volume><PubDate><Year>2020</Year></PubDate></JournalIssue><Title>Advances in experimental medicine and biology</Title><ISOAbbreviation>Adv Exp Med Biol</ISOAbbreviation></Journal><ArticleTitle>Erythropoietin Signaling in the Microenvironment of Tumors and Healthy Tissues.</ArticleTitle><Pagination><MedlinePgn>17-30</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/978-3-030-35582-1_2</ELocationID><Abstract><AbstractText>Erythropoietin (EPO), the primary cytokine of erythropoiesis, stimulates both proliferation and differentiation of erythroid progenitors and their maturation to red blood cells. Basal EPO levels maintain the optimum levels of circulating red blood cells. However, during hypoxia, EPO secretion and its expression is elevated drastically in renal interstitial fibroblasts, thereby increasing the number of erythroid progenitors and accelerating their differentiation to mature erythrocytes. A tight regulation of this pathway is therefore of paramount importance. The biological response to EPO is commenced through the involvement of its cognate receptor, EPOR. The receptor-ligand complex results in homodimerization and conformational changes, which trigger downstream signaling events and cause activation or inactivation of critical transcription factors that promote erythroid expansion. In recent years, recombinant human EPO (rEPO) has been widely used as a therapeutic tool to treat a number of anemias induced by infection, and chemotherapy for various cancers. However, several studies have uncovered a tumor promoting ability of EPO in man, which likely occurs through EPOR or alternative receptor(s). On the other hand, some studies have demonstrated a strong anticancer activity of EPO, although the mechanism still remains unclear. A thorough investigation of EPOR signaling could yield enhanced understanding of the pathobiology for a variety of disorders, as well as the potential novel therapeutic strategies. In this chapter, in addition to the clinical relevance of EPO/EPOR signaling, we review its anticancer efficacy within various tumor microenvironments.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Wuling</ForeName><Initials>W</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, China.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Varier</LastName><ForeName>Krishnapriya M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Medical Biochemistry, Dr. A.L.M. Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, India.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sample</LastName><ForeName>Klarke M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Central Laboratory, Guizhou Provincial People's Hospital, The Affiliated Hospital of Guizhou University, Guiyang, Guizhou, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zacksenhaus</LastName><ForeName>Eldad</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Medicine, University of Toronto, Toronto, ON, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Advanced Diagnostics, Toronto General Research Institute, University Health Network, Toronto, ON, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gajendran</LastName><ForeName>Babu</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, China. babug1986@gmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China. babug1986@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ben-David</LastName><ForeName>Yaacov</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, Guizhou, China. yaacovbendavid@hotmail.com.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academic of Sciences, Guiyang, Guizhou, China. yaacovbendavid@hotmail.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Adv Exp Med Biol</MedlineTA><NlmUniqueID>0121103</NlmUniqueID><ISSNLinking>0065-2598</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017467">Receptors, Erythropoietin</NameOfSubstance></Chemical><Chemical><RegistryNumber>11096-26-7</RegistryNumber><NameOfSubstance UI="D004921">Erythropoietin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D004920" MajorTopicYN="N">Erythropoiesis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004921" MajorTopicYN="N">Erythropoietin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006262" MajorTopicYN="Y">Health</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009369" MajorTopicYN="N">Neoplasms</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017467" MajorTopicYN="N">Receptors, Erythropoietin</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="Y">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D059016" MajorTopicYN="Y">Tumor Microenvironment</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Anemia</Keyword><Keyword MajorTopicYN="N">EPOR</Keyword><Keyword MajorTopicYN="N">Erythropoiesis</Keyword><Keyword MajorTopicYN="N">Erythropoietin</Keyword><Keyword MajorTopicYN="N">HIF1</Keyword><Keyword MajorTopicYN="N">Hematopoietic stem cells</Keyword><Keyword MajorTopicYN="N">Hypoxia</Keyword><Keyword MajorTopicYN="N">KIT</Keyword><Keyword MajorTopicYN="N">Leukemia</Keyword><Keyword MajorTopicYN="N">Leukemia inhibition</Keyword><Keyword MajorTopicYN="N">SCF</Keyword><Keyword MajorTopicYN="N">Signal transduction</Keyword><Keyword MajorTopicYN="N">Solid tumors</Keyword><Keyword MajorTopicYN="N">Tumor microenvironment</Keyword><Keyword MajorTopicYN="N">Tumor progression</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>2</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>2</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">32030683</ArticleId><ArticleId IdType="doi">10.1007/978-3-030-35582-1_2</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Inde</li><li>République populaire de Chine</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Wuling" sort="Liu, Wuling" uniqKey="Liu W" first="Wuling" last="Liu">Wuling Liu</name></noRegion><name sortKey="Ben David, Yaacov" sort="Ben David, Yaacov" uniqKey="Ben David Y" first="Yaacov" last="Ben-David">Yaacov Ben-David</name><name sortKey="Ben David, Yaacov" sort="Ben David, Yaacov" uniqKey="Ben David Y" first="Yaacov" last="Ben-David">Yaacov Ben-David</name><name sortKey="Gajendran, Babu" sort="Gajendran, Babu" uniqKey="Gajendran B" first="Babu" last="Gajendran">Babu Gajendran</name><name sortKey="Gajendran, Babu" sort="Gajendran, Babu" uniqKey="Gajendran B" first="Babu" last="Gajendran">Babu Gajendran</name><name sortKey="Liu, Wuling" sort="Liu, Wuling" uniqKey="Liu W" first="Wuling" last="Liu">Wuling Liu</name><name sortKey="Sample, Klarke M" sort="Sample, Klarke M" uniqKey="Sample K" first="Klarke M" last="Sample">Klarke M. Sample</name></country><country name="Inde"><noRegion><name sortKey="Varier, Krishnapriya M" sort="Varier, Krishnapriya M" uniqKey="Varier K" first="Krishnapriya M" last="Varier">Krishnapriya M. Varier</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Zacksenhaus, Eldad" sort="Zacksenhaus, Eldad" uniqKey="Zacksenhaus E" first="Eldad" last="Zacksenhaus">Eldad Zacksenhaus</name></region><name sortKey="Zacksenhaus, Eldad" sort="Zacksenhaus, Eldad" uniqKey="Zacksenhaus E" first="Eldad" last="Zacksenhaus">Eldad Zacksenhaus</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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